Special Issue "Synthesis and Applications of Oligonucleotide Conjugates".
نویسنده
چکیده
The underlying idea of oligonucleotide conjugates is to provide oligonucleotide with some novel property [...].
منابع مشابه
Synthesis of oligonucleotide-peptide conjugates for biomedical and technological applications.
Oligonucleotide-peptide conjugates have attracted considerable interest especially for biomedical uses. In the first part of this chapter, we describe protocols for the stepwise synthesis of oligonucleotides carrying peptide sequences at the 3'-end on a single support. The resulting oligonucleotide-peptide conjugates may be used as exogenous effectors for the specific control of gene expression...
متن کاملSynthesis of polyvinyl pyridine/C60 conjugates in supercritical carbon dioxide*
In the present investigation efforts have been made to synthesis polyvinyl pyridine (PvPy) /C60 conjugates through 2, 2-azobisisobutyronitrile (AIBN) initiated insitu polymerization of PvPy in scCO2.The process of synthesis was monitored under different reaction conditions ranging 1200-1800psi, 60-90 oC over 6 hours. The progress of polymerization was monitored rheoviscometrically. The concentr...
متن کاملPeptide Conjugates of Oligonucleotide Analogs and siRNA for Gene Expression Modulation
18.1 The Challenge of Delivery of Oligonucleotide Analogs and siRNA into Cells in Culture and In Vivo ............................................ 313 18.2 Chemical Synthesis of Peptide–Oligonucleotide Conjugates .............. 314 18.2.1 Synthesis of CPP Conjugates to Phosphate-Containing Oligonucleotides ...................................................................... 315 18.2.2 Synthes...
متن کاملPreparation of gold nanoparticle-DNA conjugates.
This unit describes the preparation of conjugates between nanometer-scale gold particles and synthetic oligonucleotides. Oligonucleotide-functionalized gold nanoparticles are finding increased use in both the construction of complex, tailored nanostructures and the optimization of DNA sequence analysis. The protocols in this unit outline the synthesis, purification, and characterization of nano...
متن کاملDesign, synthesis and biological evaluation of Ciprofloxacin- peptide conjugates as anticancer agents
Cancer has emerged as a leading cause of death throughout the world. Peptides are a novel class of anticancer agents that can specifically target cancer cells with low toxicity to normal tissues and thus, offer new opportunities for future cancer treatment. On the other hand, Ciprofloxacin, an antibiotic, also known to its anticancer property for enabling cell cycle arrest and creating double s...
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عنوان ژورنال:
- Molecules
دوره 22 10 شماره
صفحات -
تاریخ انتشار 2017